What is Known of the Contribution of Cellular Senescence to Osteoporosis – Fight Aging!

Cellular senescence plays a crucial role in the development of osteoporosis, a common age-related condition. As cells reach their division limit or experience damage, they enter a senescent state and secrete harmful signals known as SASP. Accumulation of senescent cells leads to chronic inflammation, tissue dysfunction, and ultimately contributes to osteoporosis. Recent studies suggest that targeting senescent cells and modulating SASP activity could be promising approaches in treating osteoporosis and other age-related disorders. Anti-senescence therapy drugs have shown potential in animal studies, but their effectiveness in clinical settings is still uncertain. Ongoing research aims to better understand the link between cellular senescence and osteoporosis to develop more targeted and effective treatments.