Researchers have developed a novel omics analysis that identifies key regulators of cell aging and rejuvenation, creating a cell rejuvenation atlas. This atlas provides insights into various rejuvenation strategies and their effects on cell behavior, offering potential targets for drug development to slow aging. The study highlights the importance of understanding molecular mechanisms underlying rejuvenation approaches and offers new perspectives on transcriptional regulators of aging and rejuvenation interventions. The findings suggest that targeting specific transcription factors like Arntl, AP-1 complex, NFE2L2, and MAF can potentially reverse age-related changes and promote cellular rejuvenation. For more information, refer to the Cell Rejuvenation Atlas research article at https://doi.org/10.18632/aging.206105.