Suppressing Inflammatory Activity of Supporting Cells in the Brain as a Treatment for ALS
New research suggests that targeting and suppressing chronic inflammation in the supporting cells of the brain could be a potential treatment for ALS. The study, conducted using animal models, found that reducing this inflammation helped to restore function. These findings offer hope for the development of anti-inflammatory strategies for human clinical trials in the future.
ALS, a neurodegenerative disease, is characterized by the loss of upper and lower motor neurons, ultimately leading to muscle atrophy and loss of motor function. The study revealed that structural changes in upper motor neurons preceded disease symptoms and triggered a protective immune response. However, prolonged presence of immune cells became toxic to neurons and led to synaptic connection loss. The research team explored the use of a semi-synthetic drug to block inflammation and observed promising results in restoring synaptic connections and improving motor neuron function. This approach shows potential for treating both familial and sporadic ALS, which are associated with inflammation.
Link: https://www.eurekalert.org/news-releases/1030785
