Positive Functions of Possibly Senescent p16-Expressing Immune Cells in Disease Tolerance – Fight Aging!

The presence of immune cells expressing markers of cellular senescence, such as p16 and β-galactosidase, raises questions about their actual senescent state. While these cells may not all be senescent, they play crucial roles in disease tolerance and healthspan extension. Clearing excess senescent cells can be beneficial if done within a short timeframe and not during infection or injury. These p16High immune cells exhibit important regulatory functions in the aged body, contributing to disease tolerance and overall survival. Understanding the role of these immune cells in disease tolerance is key to enhancing healthspan.