Oxidative Stress and Cellular Senescence in Alzheimer’s Disease
In this article, the authors delve into the connection between oxidative stress and the increasing presence of senescent cells in the brain, both of which are believed to play a role in neurodegenerative conditions like Alzheimer’s disease. The complexities of brain aging involve a multitude of processes, causes, and effects, making it challenging to pinpoint the most crucial factors. However, interventions targeting senescent cells are now feasible and being tested in clinical trials, while addressing oxidative stress without affecting other factors presents a greater challenge.
The redox process and cellular senescence are integral to various physiological functions but are also implicated in the pathological processes underlying age-related neurodegenerative disorders, including Alzheimer’s disease. This review focuses on how changes in the redox system and cellular senescence contribute to AD and how they are affected by perturbations in heme metabolism and mitochondrial function. It also explores potential therapeutic strategies that target these changes, although more research is needed to bring them into clinical use.
Link: https://doi.org/10.1016/j.redox.2024.103048
