Klotho, a protein associated with longevity, has shown to impact lifespan in mice and aging in humans. Higher levels of the soluble form of α-klotho are linked to better aging outcomes, while lower levels are associated with negative effects. Recent research highlights the role of klotho in reducing inflammation related to osteoarthritis, showcasing its potential as an anti-inflammatory agent. While primarily active in the kidney, klotho also demonstrates benefits for cognitive function and possibly other organs. The systemic immune-inflammation index (SII) serves as a useful tool for evaluating inflammation levels in the body, with studies indicating a negative correlation between SII and serum klotho concentrations in osteoarthritis patients. This finding suggests that klotho may have a role in mitigating inflammation in OA, presenting a potential target for treatment. Further studies are needed to establish a definitive causal relationship between SII and klotho levels.
Previous research has elucidated the various anti-aging mechanisms of the Klotho gene, including antioxidant, anti-inflammatory, and kidney protection properties. This study aimed to explore the association between SII and serum klotho concentrations in OA patients, revealing a significant negative relationship between the two variables. A higher SII was found to be linked to lower serum klotho levels, indicating the potential of klotho as an anti-inflammatory therapy for OA. Prospective cohort studies are needed to confirm the causal relationship between SII and serum klotho concentrations.
