Intermittent Fisetin Supplementation Improves Vascular Function in Old Mice
Recent research has shown promising results regarding the effects of intermittent fisetin supplementation on improving vascular function in old mice. Despite previous findings that fisetin supplementation did not extend the lifespan of mice, this study demonstrated that it cleared senescent cells and subsequently improved function in older mice. The reduction of cellular senescence and senescence-associated secretory phenotype (SASP) resulted in improved arterial function, indicating the potential benefits of fisetin supplementation in addressing age-related arterial dysfunction. The findings from this study suggest that fisetin may be a promising therapy for targeting excess cell senescence to treat age-related arterial dysfunction in humans.
The study also found that fisetin supplementation decreased cellular senescence in human endothelial cell culture and reduced SASP-related inflammation in old mice. The improved vascular function was attributed to increased nitric oxide bioavailability and reduced oxidative stress. Arterial stiffness was also lower in fisetin-treated mice, accompanied by favorable arterial wall remodeling. These promising findings identify fisetin as a potential therapy for clinical translation in targeting age-related arterial dysfunction. More information can be found in the research article published here.
