Age-Related Changes in mTORC1-Related Nutrient Sensing Degrade Intestinal Stem Cell Function
Dysregulation of nutrient sensing is a hallmark of aging, and this study shows the impact of this dysregulation on stem cell function in the intestines. While it may not be the root cause of aging, therapies targeting the root causes may restore more youthful nutrient sensing.
The adult intestine adapts to nutrient availability through dynamic regulation of intestinal stem cell proliferation and differentiation. This study reveals that mTORC1 activation affects cell size, number, and differentiation in a region-specific manner. In aged flies, mTORC1 signaling is disrupted, but lifelong intermittent fasting can mitigate this. In conclusion, mTORC1 signaling plays a role in ISC fate decision, allowing regional control of intestinal cell differentiation in response to nutrition.
Link: https://doi.org/10.1126/sciadv.adi2671
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“Age-Related Changes in mTORC1-Related Nutrient Sensing Degrade Intestinal Stem Cell Function – Fight Aging!
Researchers have found that age-related changes in the mTORC1-related nutrient sensing pathway can impact the function of intestinal stem cells. This dysregulation of nutrient sensing is a key aspect of aging, and while it may not be the primary cause, addressing it could help restore more youthful nutrient sensing. The study also revealed that mTORC1 activation influences cell size, number, and differentiation in the intestines, with implications for aging-related disruptions. Strategies such as lifelong intermittent fasting show promise in mitigating these disruptions. This research sheds light on the role of nutrient sensing in intestinal cell differentiation and its impact on aging, paving the way for potential interventions to maintain intestinal stem cell function in older individuals.”
