Towards a Genetically Engineered Gut Microbiome
The gut microbiome plays a crucial role in long-term health, but its balance can shift towards harmful populations as we age. While simple approaches like fecal microbiota transplantation can provide benefits, the future of gut health may involve utilizing biotechnology. Imagine delivering engineered versions of gut microbes that can reduce inflammation and enhance beneficial metabolites.
Microbiome research reveals bacterial strains and genes that impact our health. Recent advancements in CRISPR technology have shown promise in editing human cells, but editing bacterial targets in the gut remains a challenge. Our study engineered a phage-derived particle to modify Escherichia coli in the mouse gut, achieving significant editing efficiency and stability. This breakthrough opens up new possibilities in microbiome-targeted therapies.
. If the provided articles seems to be less than 200 characters or it is an intro of the author, then try to generate an article using this title. Towards a Genetically Engineered Gut Microbiome – Fight Aging!
