The Longevity-Associated Gene INDY as a Target for Treatment of Osteoporosis
INDY is a well-studied gene associated with longevity and has been linked to increased lifespan in various laboratory species. This article argues that inhibiting INDY could potentially be used in the treatment of osteoporosis, a condition characterized by age-related loss of bone density. The research highlights the role of SLC13A5, also known as INDY, in regulating citrate uptake and production within bones, and how disrupting this pathway impairs bone mineralization. Furthermore, studies indicate that reduced SLC13A5 function could lower the risk of osteoporosis, suggesting it as a potential treatment target. For more information, you can access the full article here.