The gut microbiome undergoes changes with age, potentially contributing to Alzheimer’s disease. While inflammation plays a role in AD, the specific impact of an Alzheimer’s-like gut microbiome remains unclear. Recent studies suggest a link between gut health and neurodegenerative disorders, including AD, offering potential for early diagnosis and treatment. Understanding the role of the gut microbiota in AD pathogenesis is crucial for identifying at-risk individuals and exploring non-pharmacotherapeutic approaches. Lifestyle factors, such as diet, play a significant role in AD development, with research focusing on the impact of different dietary patterns on AD neuropathological markers. The link between gut microbiota, diet, and AD underscores the importance of further research in this area. For further reading, visit: https://doi.org/10.3390/nu16030412.