Research shows that TDP-43, a protein associated with neurodegenerative disorders, may play a role in vascular dysfunction and blood-brain barrier integrity. This protein is crucial for various processes, and its deficiency could contribute to vascular issues seen in conditions linked to TDP-43 aggregates. The disruption of the blood-brain barrier can lead to inflammatory responses and potential damage in the brain. Understanding the impact of TDP-43 in endothelial cells might provide insights into the development of neurological disorders. Further investigation is needed to determine the significance of TDP-43 in maintaining a healthy vasculature.
Recent studies highlight the importance of TDP-43 in endothelial cells and its role in angiogenesis and vascular function. Loss of TDP-43 in endothelial cells leads to vascular abnormalities and triggers neuroinflammation. These findings suggest that TDP-43 is essential for the formation of a stable and functional vasculature, emphasizing its potential impact on overall brain health.
