Targeting siRNA to Microglia to Suppress PU.1 Expression and Reduce Neuroinflammation – Fight Aging!

Researchers have developed a method to target microglia in the brain with small interfering RNA (siRNA) to reduce PU.1 protein expression, which is involved in regulating inflammation in microglia. Chronic inflammation driven by microglia is linked to aging and neurodegenerative conditions, including Alzheimer’s disease. In a recent study, researchers showed that blocking PU.1 protein activity reduced Alzheimer’s disease-related neuroinflammation and pathology. However, delivering siRNA to suppress PU.1 expression in microglia proved challenging, as existing reagents were ineffective. The team optimized a lipid nanoparticle (LNP) called “MG-LNP” to successfully deliver the siRNA in both human cell cultures and mice, resulting in a reduction of PU.1 expression and inflammatory markers. The study demonstrates the potential of using siRNA to target microglia and reduce neuroinflammation, offering promising therapeutic implications for neurodegenerative conditions. For more information, visit the link here.