Sirtuin 2 Overexpression Fails to Extend Life in Mice – Fight Aging!

Sirtuin 2 overexpression was thought to potentially impact overall lifespan in mice, but a recent study has found that this is not the case. Despite previous research indicating that SIRT2 might play a role in aging and age-related diseases, the latest findings show that overexpression of SIRT2 does not have an impact on overall health or lifespan in mice. This suggests that levels of this protein are not relevant to functional biological aging and lifespan under standard conditions. The study also highlighted the complexity of sirtuin proteins and their potential role in various age-related conditions, such as neurodegenerative diseases and tumor growth. Despite the continued research on sirtuins, including other members of the family, the quest for interventions to extend lifespan in mammals remains challenging.