Reviewing the Development of Senotherapeutics to Treat Aging – Fight Aging!

Cellular senescence is a key factor in aging and the development of age-related diseases. The activation of senescence in cells, triggered by various stress signals, contributes to chronic inflammation and age-related functional decline. As a result, there is a significant effort in finding and developing senotherapeutics to selectively target and destroy senescent cells, as well as suppress their phenotypes without causing cell death. This development represents a promising strategy in combating aging and age-related diseases. Immune cell-mediated clearance of senescent cells is also being explored as a potential therapy. Understanding the immune reaction to senescent cells is crucial in achieving extreme longevity. For more information, refer to: Link: https://doi.org/10.3390/ijms25031792