Reviewing the Data on Human Use of Rapamycin – Fight Aging!
Rapamycin and its derivatives, known as rapalogs, are inhibitors of mTOR, a key regulator of the aging process. Numerous studies have shown that rapamycin and its derivatives have the potential to improve various physiological systems in humans, including the immune, cardiovascular, and integumentary systems. However, the effects on the endocrine, muscular, and neurological systems remain inconclusive.
While rapamycin has been shown to enhance learning and memory in animal models, the same effects were not observed in human studies. Additionally, the effects on aging-related macular changes were inconsistent. Rapamycin also has implications for glucose metabolism and has been hypothesized to play a crucial role in maintaining skeletal muscle mass.
It is important to note that the relationship between the dose of rapamycin and its efficacy in ameliorating aging-related outcomes is not yet fully understood. Further research is needed to establish an appropriate dosing regimen for geroprotection.
Overall, the data on the human use of rapamycin and its derivatives show promise in various physiological systems, but more comprehensive studies are needed to fully understand their effects on aging and longevity in humans.
