Resolvin D2 Treatment Increases Monocyte Production and Slows Liver Aging in Mice
This study explores a potential method to regulate the production of monocytes in the bone marrow, which develop into macrophages of the innate immune system. The findings show that a single treatment has a lasting impact on the progression of liver aging in mice, leading to reduced inflammation-related pathology such as fibrosis. The study also reveals that providing aged bone marrow to young mice accelerates liver pathology. Fibrosis, the excessive production of collagen structures, disrupts tissue function and is challenging to treat.
Aging is linked to unresolved inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts via the G-protein-coupled receptor GPR18. This study demonstrates that RvD2-GPR18 signaling controls steatosis and fibrosis, providing a potential mechanism-based therapy for promoting liver repair in aging. The study also highlights the potential of RvD2 treatment to regulate monocyte production, macrophage generation, and liver aging in mice.
Link: https://doi.org/10.1016/j.ajpath.2023.08.011
