OXR1 and Retromer Function in Aging
Researchers have discovered that the gene OXR1 plays a crucial role in retromer function, which is important in aging and disease. As the expression of OXR1 declines with age, it is seen as a potential target for therapies to slow age-related cellular dysfunction. The study also found that dietary restriction influences the expression of OXR1 and its interaction with the retromer, shedding light on the mechanism of delaying aging through diet.
Further research showed that loss of OXR1 destabilizes the retromer, leading to improper protein trafficking and endolysosomal defects. However, overexpression of retromer genes or pharmacological restabilization rescued lifespan and neurodegeneration related to OXR1 deficiency. The findings indicate that OXR1 is critical for preserving retromer function and is essential for neuronal health and longevity.
