NRF1 is Neuroprotective via Proteasomal Function – Fight Aging!
Cells have various maintenance processes to protect themselves from damage and stress, including autophagy and the ubiquitin-proteasome system. Upregulation of these processes has been shown to improve resistance to cell stress and contribute to long-term health. Researchers are exploring the potential of upregulating NRF1 (also known as NFE2L1) to improve proteasomal function, particularly in the context of neurodegenerative diseases. NRF1 plays a crucial role in regulating antioxidant and stress-responsive genes, as well as proteasome subunits. Studies have shown that NRF1 deficiency is associated with neurodegenerative diseases, making it a promising therapeutic target. However, achieving neuron-specific activation of NRF1 would be important to minimize off-target effects.
