The ever-shifting epigenetic marks on the genome play a crucial role in determining gene expression and protein production in cells. With age, epigenetic regulation changes in ways that can be detrimental, leading to interest in epigenetic reprogramming to restore a youthful state. While still a work in progress, early studies show promise in animal models.
Neurons undergo significant changes in structure and function throughout life, impacting neuronal signaling and cognitive processes in the aging brain. Aging affects different neuron types in various brain regions, particularly the hippocampus and prefrontal cortex, essential for memory and cognitive flexibility.
Neurons, being one of the oldest cell types in the body, rely on maintaining their molecular identity and plasticity for lifelong function. However, aging-related impairments in gene expression programs and epigenetic regulation contribute to neuronal dysfunction. Rejuvenating interventions, like lifestyle changes and cellular reprogramming, offer hope in reversing neuronal epigenetic aging for potential anti-aging strategies.
