Age-related hearing loss (ARHL), the third most common chronic geriatric disease, affects about half of adults over 85 years old. This condition significantly impairs health and well-being, leading to communication challenges, social isolation, and cognitive decline. The relationship between aging and ARHL is complex, as aging processes contribute to auditory deterioration. Understanding the molecular and cellular mechanisms underlying ARHL is crucial for developing interventions. Dysregulation of cellular and molecular pathways like senescence, autophagy, and oxidative stress play a role in hearing loss progression, but specific causative factors are still unknown. Calorie restriction has shown promise in slowing ARHL, and targeting oxidative stress and mitochondrial dysfunction may offer new treatment strategies. By characterizing these aging pathways, we can enhance our understanding of aging and its impact on ARHL.
Mechanisms of Aging in Age-Related Hearing Loss – Fight Aging!
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