LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy – Fight Aging!

The LEV Foundation is focused on demonstrating that therapies aimed at repairing molecular damage that causes aging can be combined to achieve greater rejuvenation. Recent research has shown that manipulating metabolism to slow aging has not been effective in combining therapies. The foundation discusses the use of senolytics in combination studies in mice as part of a larger effort to develop rejuvenation therapies. The use of senolytics aims to deliberately eliminate senescent cells, which have been associated with various health benefits in animal studies. The foundation is conducting Robust Mouse Rejuvenation studies to investigate the potential lifespan-enhancing effects of combining therapies, including senolytic intervention. The use of senolytics is believed to synergize with other rejuvenation therapies by reducing the burden of senescent cells. By combining senolytics with other interventions, such as rapamycin and stem cell transplantation, the foundation hopes to achieve greater reduction in senescent cell prevalence and ultimately, rejuvenation.