Researchers have been focusing on analyzing the CALERIE 2 study on human calorie restriction, with new results continuing to be published. The study shows inconclusive effects on telomere length and aging clocks. Telomere length in white blood cells is not a reliable measure of aging due to individual variability and daily immune changes. Aging clocks derived from omics data are more promising. The CALERIE 2 trial tested caloric restriction’s impact on lifespan and aging biology in humans, with mixed results on telomere length attrition. Further research is needed to determine the long-term effects of caloric restriction on telomere fidelity.
Caloric restriction modifies lifespan and aging biology in animal models, and the CALERIE 2 trial aimed to translate these findings to humans. The study found no significant differences in telomere length attrition in the first year, but trends suggest potential effects of caloric restriction. Further analysis is needed to understand the overall impact of caloric restriction on telomere length over time.