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Contents:
LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy
The Longevity Escape Velocity (LEV) Foundation aims to demonstrate that the repair of molecular damage causing aging can be combined to produce greater rejuvenation. This approach is an alternative strategy in contrast to manipulating metabolism into a state where aging occurs more slowly, which has shown to not be very promising. This article discusses the use of senolytics to clear senescent cells in combination studies in mice, and its relevance to producing rejuvenation when combined with other therapeutic approaches.
The Case For: Senolytics
The flagship research program at LEVF is the Robust Mouse Rejuvenation (RMR) studies. In this program, the potential lifespan-enhancing effects of combining multiple interventions in middle-aged mice have been tested. This includes using senolytics as one of the interventions administered in combination to study mice at Ichor Life Sciences. The essay addresses the role of cellular senescence in aging and the role of senolytic therapies in rejuvenation and speculates on how reducing the burden of senescent cells might synergize with other rejuvenation therapies.
Commentary on Gaps in the Knowledge of Aging
This article highlights the gaps in understanding how aging progresses at the detail level and the complexities of aging as a universal process. There are significant gaps in comprehending the evolution of aging and how it became near universal across the tree of life. These complexities exist due to the intricate systems that make up living organisms.
