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Find thought-provoking commentary on the topic of vascular aging and peripheral nervous system aging in a new study released today. Researchers discuss the impact of these processes on the heart. The study reveals a signal released by endothelial heart cells that can be disruptive to peripheral nerve maintenance. This presents a target for drug development and further study into this form of degenerative aging.
Alzheimer’s patients often exhibit cerebral amyloid angiopathy, or an accumulation of amyloid-β in blood vessel walls. This can lead to blood-brain barrier dysfunction, which can then cause further damage to the brain. Researchers explore the mechanisms behind the cause and effect of amyloid-β aggregation and blood-brain barrier leakage. This is an example of an argument for a particular direction of causation between processes known to be involved in Alzheimer’s disease.
The research also offers insight into the role of CCL17 in inflammation and cardiovascular disease. This study provides clarity on the significance of CCL17 as a target to reduce inflammation in cardiovascular disease.
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