Exosomes, small membrane-wrapped packages of diverse molecules, play a critical role in cellular communication. They have emerged as a promising therapeutic option for treating various diseases, including skin aging. This review focuses on the potential of exosomes, particularly those derived from stem cells, in addressing skin photoaging. Preclinical studies have shown that stem cell-derived exosomes can restore skin function, regenerate damaged tissue, and modulate cellular processes, making them an exciting prospect for the treatment of skin aging. For more information, you can refer to the following link: https://doi.org/10.1186/s12964-023-01451-3.