Efferocytosis, the process of clearing dying cells and debris by phagocytes like macrophages, plays a crucial role in maintaining tissue health and preventing inflammation. Enhancing efferocytosis has the potential to improve cellular regeneration and combat age-related diseases such as atherosclerosis, cancer, and diabetes. This review explores the significance of efferocytosis in aging, its impact on age-related disorders, and potential therapeutic interventions. The integration of strategies to boost efferocytic mechanisms with anti-aging treatments could offer promising outcomes for extending a healthy lifespan. (Link: https://doi.org/10.1016/j.jare.2024.03.008)