Continued Efforts to Produce Universal Pluripotent Stem Cells – Fight Aging!

Researchers have made significant progress in developing pluripotent stem cell lines that can evade immunological rejection when transplanted into other individuals, or even between species. This breakthrough holds promise for the future of regenerative medicine, allowing for the production of universal donor cells and tissues at a reasonable cost. The findings offer hope for treating diseases such as Type 1 diabetes and macular degeneration. Using CRISPR-Cas9 technology, the researchers identified and removed specific genes involved in immune rejection from human pluripotent stem cells. Testing in mice with fully functioning immune systems showed promising results, with the genetically engineered stem cells integrating and persisting without rejection. While progress in this field has been slow and challenging, these advancements are a step forward in the development of safe and effective pluripotent stem cell-based therapies. For more information, visit: https://healthsciences.arizona.edu/news/releases/researchers-genetically-modified-stem-cells-evade-immunological-rejection