CISD2, a pro-longevity gene, has been shown to decline with age. However, upregulation of CISD2 expression has been found to improve liver function and extend lifespan in mice. This approach is expected to have broad effects on many tissues beyond the liver, including the skin. By increasing the efficiency of cell maintenance processes such as autophagy, CISD2 upregulation reduces senescent cell burden and suppresses the harmful senescence-associated secretory phenotype (SASP). Researchers have demonstrated this benefit in aged skin, showcasing the potential for CISD2 upregulation as a strategy to combat skin aging.
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