Researchers are currently focused on finding ways to reduce the impact of senescent cells on aging, particularly in the skin. Aging is associated with a range of visible signs, accelerated by factors like UV radiation, genetics, and hormonal changes. At the cellular level, aging is linked to various processes, including cellular senescence, which leads to impaired tissue repair and regeneration, as well as the promotion of inflammation. This review discusses the role of cellular senescence in skin aging and potential strategies to rejuvenate aged skin.
The skin, as the body’s largest organ, is where aging signs such as thin and dry skin, sagging, wrinkles, and pigmentation changes are most noticeable. These features are accelerated by external and internal factors, and aging is also associated with cellular changes including senescence, which negatively impacts tissue homeostasis and repair. Suggested strategies for rejuvenating aged skin are also considered here.
