Myelin is crucial for the functioning of the nervous system, and diseases like multiple sclerosis result from its loss. Aging also leads to demyelination, and chronic inflammation plays a role. Calorie restriction can help reduce inflammation and promote favorable changes in cells that contribute to inflammatory signaling. Calorie restriction mimetic drugs are of interest, but they don’t fully replicate the effects of actual calorie restriction.
Demyelination in the central nervous system can lead to axonal degeneration and impairments. Glial cells, including microglia and astrocytes, play a crucial role in myelin formation and remyelination. Modulating the profile of glial cells can enhance successful remyelination, and substances known as caloric restriction mimetics have been shown to slow the aging process by influencing the autophagic processes in myelinating glial cells.
Link: https://doi.org/10.3390/cimb45120596
