A recent study has shown that the administration of angiotensin (1-7) protein to injured muscles in mice leads to improved regeneration of muscle tissue. While protein therapies are currently expensive, gene therapies are becoming more promising for increasing levels of circulating proteins. Research in this area is focused on finding small molecules that upregulate expression of the desired protein. This study aims to investigate the role of Angiotensin (1-7) in skeletal muscle regeneration, with promising results for treating muscle-related disorders.
The study found that C2C12 myotubes incubated with Ang-(1-7) showed larger diameters and increased myogenin and MHC protein levels during differentiation, while administration of Ang-(1-7) in mice also led to improved muscle regeneration. The findings suggest that Ang-(1-7) has the potential to effectively promote differentiation in vitro and improve muscle regeneration in the context of injuries.
For more information, the study can be accessed via the link: https://doi.org/10.4081/ejtm.2023.12037
