Alzheimer’s disease is a common, progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. Recent studies have suggested a potential link between human growth hormone treatments and the development of Alzheimer’s disease. Researchers from the University College London (UCL) discovered a possible connection between individuals treated with cadaver-derived human growth hormone (c-hGH) between 1959 and 1985 and the later development of symptoms of dementia, including Alzheimer’s disease.
Understanding Alzheimer’s Disease
Alzheimer’s disease is caused by the accumulation of abnormal protein aggregates, disrupting communication between brain cells, leading to their gradual degeneration and eventual loss. This disruption is likened to a traffic jam in the brain, where the build-up of proteins disrupts cell communication and function.
Human Growth Hormone and Human Growth Hormone Treatments
Human growth hormone (HGH) is naturally produced by the pituitary gland and plays a crucial role in growth, cell regeneration, and maintaining healthy body tissues. Synthetic versions have been used for various medical purposes, including treating growth hormone deficiencies and certain conditions affecting height, as well as for illegal purposes by athletes and bodybuilders.
The Study and Its Findings
Research revealed that individuals treated with c-hGH had an increased risk of developing Alzheimer’s disease, as the c-hGH used in the treatments had been contaminated with amyloid-beta proteins.
Implications and Limitations
Although the use of c-hGH from deceased persons’ brains as a treatment was discontinued in 1985, the study’s findings highlight the importance of preventing accidental transmission of amyloid-beta in other medical and surgical procedures.
Preventing the Development of Alzheimer’s Disease
While no guaranteed way exists to prevent Alzheimer’s disease, certain lifestyle choices and interventions may help reduce the risk or delay its onset, including regular exercise, a healthy diet, mental stimulation, social engagement, quality sleep, managing chronic conditions, and staying mentally and emotionally healthy.
The Bottom Line
The study’s findings encourage further caution and investigation to mitigate potential risks and safeguard patient well-being, while adopting a healthy lifestyle can potentially reduce the risk of developing Alzheimer’s disease and support overall brain health.
Sources
- “What is Alzheimer’s Disease?” ALZ
- “Traffic jam hypothesis: Relationship between endocytic dysfunction and Alzheimer’s disease.” Pubmed. Nobuyuki Kimura and Katsuhiko Yanagisawa. October 2018.
- “Human growth hormone.” Health Direct
- “Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone.” Nature. Gargi Banerjee, Simon F. Farmer, Harpreet Hyare, Zane Jaunmuktane, Simon Mead, Natalie S. Ryan, Jonathan M. Schott, David J. Werring, Peter Rudge and John Collinge. January 29, 2024.
- “Reducing Risk of Alzheimer’s Disease.” CDC