Partial epigenetic reprogramming is a key area of interest in understanding how cells behave in cancerous tissue and during embryonic development. This process involves the resetting of epigenetic markers in the genome, allowing for a more youthful pattern of gene expression. While some genes involved in this process also operate in cancers, there is potential for targeting the regulatory systems controlling cell type change and restoration of youthful epigenetic markers. This could lead to rejuvenation therapies that reset the epigenetics of aged cells, making them more youthful and improving the function of tissues and organs. Despite the significant investment in epigenetic reprogramming ventures, there are still unanswered questions and challenges to be addressed. As the field continues to advance, it is important to consider the potential impact on longevity research and the ethical implications of these emerging findings.