The field of stem cell therapy is advancing with new approaches to treatment. One reason for this evolution is the complexity of working with cells for therapy, as meeting regulatory standards is challenging. Stem cell transplantation benefits elderly patients through signaling effects rather than cell activity. As a result, there is a shift towards using cell products like extracellular vesicles or the secretome – all molecules released by cells into the extracellular medium. Immunis Biomedical is working on standardizing stem cell secretome therapies for clinical use. This approach improves metabolism, reduces fat, and enhances muscle function in aged mice.
Aging is associated with muscle loss, increased fat, and decreased physical function. To combat these effects, researchers tested a stem cell secretome product containing extracellular vesicles and growth factors. Injections of the secretome in aged mice led to increased lean mass, decreased fat mass, improved physical function, and enhanced muscle and adipose tissue health. The data suggests that stem cell secretome treatment can improve overall health in elderly individuals.
