A Role for the Gut Microbiome in the Aging of the Ovaries
The aging of the ovaries, much like the thymus, is a significant issue as it occurs at an accelerated pace compared to the rest of the body. Researchers have found that changes in the balance of microbial populations in the gut microbiome may contribute to this early loss of function. Age-related changes in the gut microbiome, where pro-inflammatory microbes increase while those producing beneficial metabolites decline, play a role in reproductive aging. Maintaining a healthy gut microbiota is suggested as a potential way to delay ovarian aging and prevent adverse outcomes. Experimental and clinical studies have revealed the relationship between gut dysbiosis and ovarian follicle development, as well as a disturbed immune response. Future studies should focus on the potential causes and underlying mechanisms to verify the beneficial effects of interventions in ovarian aging.
Altered composition and function of the gut microbiota play an important role in the pathogenesis of reproductive aging. Results from fecal microbiota transplant (FMT) studies provide new insights into anti-ovarian aging, suggesting that maintaining youthful gut microbiota helps preserve ovarian function and prevent ovarian-related diseases. Microbiota-based intervention to delay or reverse ovarian aging is an appealing approach and may offer new therapeutic strategies for intestinal microbiota regulation to improve female fertility.
Furthermore, investigation of anti-aging interventions such as drugs and calorie restriction may improve the gut microbial imbalance and promote a healthier intestinal ecological environment. Imbalance in the gut microbiota may lead to the progression of various ovarian aging-related conditions. Although ovarian aging is unavoidable, maintenance of a balanced gut microbiota is a potential way to delay ovarian aging and subsequent adverse outcomes.
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