There are currently two perspectives on the impact of stochastic DNA damage on aging. The first suggests that mutational damage in stem cells can spread throughout tissue over time, while the second focuses on changes in gene expression resulting from DNA damage and repair processes. An article on RNA polymerase II dysfunction in aging animals further supports the link between DNA damage and aging-related changes in gene expression and cell behavior.
A popular science article presents a study on older mice, showing that RNA polymerase II often stalls while transcribing DNA into RNA. This stalling can lead to disrupted gene expression, affecting cellular pathways crucial for healthy functioning and longevity. The study also suggests a potential link between DNA damage and aging, with genetically altered mice lacking DNA repair machinery exhibiting features of premature aging and a decreased transcription rate. These findings support the idea that DNA damage may contribute to the aging process.
