A novel proteomic aging clock has been developed using a large proteomic cohort in the UK Biobank, with the aim of creating a surrogate biological age for all-cause mortality risk. The proteomic aging clock showed strong associations with mortality and multiple incident diseases, and outperformed other biological age measures. The proteins associated with the proteomic aging clock deviation are enriched in various hallmarks of biological aging. Standardizing a single clock and understanding its relation to underlying aging processes is crucial for advancing research in this area.
Link: https://doi.org/10.1101/2023.12.19.23300228