Age-related frailty is not inevitable, and can be postponed for decades and even reversed in early old age with sufficient effort put into treatment and lifestyle changes, particularly those involving resistance exercise. A recent study shows that those who managed to reverse their frailty had a reduced risk of mortality and cardiovascular disease. This highlights the need to develop therapies that can effectively reverse frailty for everyone by targeting the driving factors of failing muscle tissue and an overly-inflammatory immune system.
The study titled “Association of changes in frailty status with the risk of all-cause mortality and cardiovascular death in older people: results from the Chinese Longitudinal Healthy Longevity Survey (CLHLS)” investigates the association of changes in frailty status with the risk of all-cause mortality and cardiovascular death in older people. The results show that improved frailty and remaining robust are significantly associated with a lower risk of all-cause mortality and cardiovascular death in older people.
