What is Known of the Age-Related Decline in Autophagy
Autophagy is a complex cellular maintenance process responsible for recycling damaged proteins. Upregulation of autophagy can slow aging, but its efficiency declines with age. The molecular mechanisms behind this decline are not fully understood due to the complexity of the process.
Studies have shown that genetic manipulations of autophagy-related genes can affect lifespan and healthspan. Understanding the age-related changes in the autophagy process may help in developing strategies to prevent decline and combat age-related diseases.
