Non-healing wounds associated with aging and inflammatory diseases like type 2 diabetes can be attributed to immune system dysfunction. Strategies targeting immune cell behavior, particularly excessive inflammation, show promise in wound healing. This paper explores the use of biomaterials in immunomodulation, focusing on scaffolding for cell therapies and tissue engineering. Enhancing therapies by modulating immune cell behavior requires a multidisciplinary approach merging immunology, biomaterial science, and nanotechnology. Understanding immune responses in chronic wound healing can lead to innovative strategies for optimizing healing processes, reducing inflammation, scarring, and infection risks. Biomaterials offer a platform for precise control over immune cell behaviors through surface modifications and bioactive agent incorporation. While current research predominantly examines macrophage behavior, further investigation is necessary to understand responses from other immune cell types and their interactions with biomaterial properties. Comprehensive knowledge in this area will help in designing multifunctional therapeutic strategies for effective immune modulation.
Using Biomaterials to Modulate the Immune System to Heal Chronic Wounds – Fight Aging!
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