Upregulation of aal1 Long Non-Coding RNA Extends Life in Flies
Researchers have discovered a long non-coding RNA in flies that slows down the creation of ribosomes, leading to a decrease in protein synthesis and ultimately extending lifespan. This finding challenges the notion that improving ribosomal function always enhances longevity, as reducing ribosomal activity has also been associated with longer lifespan in certain contexts like calorie restriction. The complexity of ribosomal activity in aging requires further investigation to fully understand its role.
Genomes produce long non-coding RNAs with unclear functions, such as aal1 (ageing-associated lncRNA), which influences the lifespan of non-dividing cells. By repressing ribosomal protein gene expression, aal1 reduces ribosome content and inhibits protein translation, contributing to increased longevity. The binding of aal1 to rpl1901 mRNA highlights its role in regulating the translational machinery in organisms.
