As individuals age, the immune system weakens, increasing the risk of sepsis, a condition where an infection can lead to life-threatening consequences. In sepsis, the kidneys are often a target, adding to the severity of the situation. This study focuses on a fungal supplement used to treat acute kidney injury caused by sepsis. It highlights the importance of enhancing mitochondrial function and shifting macrophage polarization towards a pro-regenerative state in treating sepsis-induced kidney dysfunction.
Sepsis-associated acute kidney injury (S-AKI) is a critical complication of sepsis, but the exact pathophysiological mechanisms are complex and not fully understood. Various processes like impaired energy metabolism, oxidative stress, and inflammation contribute to S-AKI, impacting renal function significantly. Mitochondrial damage plays a key role in kidney injury, while macrophage polarization influences the progression of S-AKI. Targeting mitochondrial health and macrophage activity could be promising strategies in managing S-AKI.
Cordyceps sinensis (CS), a fungus with medicinal properties, has shown potential in protecting renal function. This study explores the effects of CS in treating sepsis-induced AKI in mice, revealing its ability to improve mitochondrial function and macrophage polarization. By targeting these pathways, CS provides therapeutic benefits in preventing and mitigating S-AKI.
Link: https://doi.org/10.15212/AMM-2024-0018
