The development of modern vaccination technology in the 20th century has been crucial in combating infectious diseases, but as individuals age, their immune system weakens, leading to decreased vaccine efficacy. To address this, researchers are exploring ways to rejuvenate the aged immune system, such as restoring active thymic tissue and clearing malfunctioning immune cells. By focusing on repairing immunosenescence, we can improve vaccination outcomes for older individuals and enhance their immune response against various pathogens. Future research should prioritize developing strategies to inhibit immunosenescence and create tailored vaccine adjuvants to bolster immunity in the elderly population. The key to the future of vaccination in older individuals lies in reversing age-related immune decline.