Telomere length is a key factor in aging and age-related diseases, making it a promising target for therapeutic interventions. Despite challenges in translating telomere research into clinical treatments, innovative strategies are essential for developing effective therapies. Telomerase gene therapy shows potential in delaying cellular aging and extending healthspan, paving the way for interventions that target the aging process itself. While human trials are still in their early stages, continued exploration and refined methodologies could revolutionize aging and disease treatment.