The presence of senescent cells in the vasculature plays a crucial role in the development of cardiovascular disease with aging. Understanding how these cells contribute to endothelial dysfunction and atherosclerosis is key in developing effective therapies. Senolytics show promise in targeting and eliminating senescent cells, improving vascular function, and reducing cardiovascular disease. While preliminary clinical trials have shown positive outcomes, more research is needed to fully understand the long-term effects of senolytic therapy on cardiovascular health. The potential of senolytics to transform age-related cardiovascular diseases is an exciting frontier that warrants further investigation.