Senescent cells in the brain play a significant role in the development and progression of age-related neurodegenerative conditions. As cells accumulate and linger due to a less efficient immune system with age, inflammation increases, worsening the prognosis for patients. Despite the strong connection between senescent cells and neurodegeneration, research and clinical trials in this area are limited. However, targeting these cells could hold promise in the treatment of central nervous system diseases. A recent small clinical trial using senolytic drugs showed promising results in Alzheimer’s patients, sparking hope for future advancements in this field.