The Ohio State University Wexner Medical Center and College of Medicine have developed a groundbreaking new tool to support Alzheimer’s disease research – the ssREAD database. Published in “Nature Communications,” this freely searchable resource contains 1,053 samples from 67 studies, totaling 7.3 million cells. Notably, data from 18 human and mouse brain studies have been included, providing a comprehensive overview for researchers.
With detailed annotations on species, gender, brain region, disease status, age, and AD Braak stages, ssREAD offers an unprecedented level of insight. Following the success of their previous database, scREAD, the team has continued to innovate in managing single-cell RNA-sequencing data.
By enhancing the database’s interface, researchers can now access more interactive visualizations, streamlining the data querying process. Ohio State’s efforts have been lauded for closing the gap in Alzheimer’s research, offering a centralized platform for integrating diverse datasets and accelerating scientific progress in this complex field.
“We are providing researchers with a specialized database that aligns with the latest technologies and design principles. This integration of data will prove invaluable for those navigating the intricate landscape of Alzheimer’s disease,” shared Dr. Qin Ma, a professor in the department of biomedical informatics at Ohio State, in an interview with Medical Xpress.
