MYC and USF1 are Downregulated in Aged Human Macrophages – Fight Aging!

Researchers delve into the age-related changes observed in macrophages and monocytes, crucial components of the immune system. Macrophages play diverse roles, from combating pathogens to aiding in tissue regeneration. Understanding these changes could offer insights into age-related diseases and potential rejuvenation strategies for immune cells.

Macrophages, pivotal in innate immunity, exhibit decreased function with age. This study reveals a decline in phagocytosis, migration, and chemotaxis in older human-derived macrophages, linked to reduced levels of MYC and USF1 transcription factors.

Knockdown of MYC or USF1 in young macrophages mimics age-related dysfunction, affecting gene expression, adhesion, and morphology. The dysregulation of MYC and USF1 in older macrophages leads to altered cell characteristics, highlighting their role in age-related macrophage decline.

Link: https://doi.org/10.1016/j.celrep.2024.114073