MTTP, known for its role in lipid metabolism and cardiovascular function, has been implicated in longevity. Researchers have utilized flies to show that the fly equivalent of MTTP, mtp, is involved in the mechanisms through which exercise improves long-term cardiac health. However, the precise involvement of MTTP or mtp in the aging process and cardiovascular health mechanisms is still not fully understood and requires further research. This study sheds light on the potential relationship between mtp and age-related diastolic dysfunction, as well as the beneficial effects of exercise on cardiac aging and lifespan in Drosophila.
Microsomal triglyceride transfer protein (mtp) in Drosophila is a direct homolog of human MTTP. MTTP has been linked to human longevity and various vascular diseases, underscoring its significance in lipid metabolism and cardiovascular health. Age-related diastolic dysfunction, a major cardiac issue, is associated with declining mtp levels, but exercise interventions appear to positively impact mtp-related pathways, potentially extending lifespan and improving cardiac function.
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